Name: U-Blot® LGR5/GPR49 Rabbit mAb
SKU: WR5199
Price: 268 USD
Availability: InStock

U-Blot® LGR5/GPR49 Rabbit mAb

Ucallm_WR5199-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR5199-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015],

Specifications

Size	50μL/100μL
Target	LGR5
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	100kD
MW(Observed)	100kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1433R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	LGR5 GPR49 GPR67
Protein Name	Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38)
Other Name
Species	Human
Gene ID	8549
Uniprot	O75473,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q9Z1P4
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). .
Tissue Expression	Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> Wnt signaling pathway
Research Areas	>>Wnt signaling pathway
Function	Function:Orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 17 LRR (leucine-rich) repeats.,tissue specificity:Expressed in skeletal muscle, placenta, spinal cord, and various region of brain.,