SKU: WM0608 Categories: ,

Rab2 mouse mAb

Price range: $268.00 through $328.00

SKU: WM0608-50
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Product details

Background:
The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Specifications

Size50μL/100μL
TargetRab 2A
ReactivityHuman
ApplicationsWB, ICC
MW(Calculated)
MW(Observed)24kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000; ICC 1:200
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number17C4
ImmunogenPurified recombinant human Rab2 protein fragments expressed in E.coli.
SpecificityThis antibody detects endogenous levels of Rab2 and does not cross-react with related proteins.
Gene NameRAB2A
Protein Name
Other Name9330148M11Rik; / C80220; / GTP binding protein; / LHX; / OTTMUSP00000004796; / RAB2; / RAB2 member RAS oncogene family; / RAB2A; / RAB2A, member RAS oncogene family; / RAB2A_HUMAN; / Ras related protein Rab 2A; / RAS-associated protein RAB2; / Ras-related protein Rab-2A; / RP23-183L6.1; / Small GTP binding protein RAB2A.
SpeciesHuman
Gene ID5862
UniprotP61019,
Species.1Mouse
Gene ID.159021
Uniprot.1P53994
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor . Melanosome . Endoplasmic reticulum membrane; Lipid-anchor . Golgi apparatus membrane; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle, acrosome . Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
Tissue ExpressionBrain,Skin,
Signaling_pathwayEnvironmental Information Processing >> Signal transduction >> AMPK signaling pathway
Research Areas>>AMPK signaling pathway
FunctionFunction:Required for protein transport from the endoplasmic reticulum to the Golgi complex.,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with PRKCI.,
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