Name: AKR1B1 mouse mAb
SKU: WM0652
Price: 268 USD
Availability: InStock

AKR1B1 mouse mAb

Ucallm_WM0652-50

Price range: $268.00 through $328.00

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SKU: WM0652-50

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Background:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009],

Specifications

Size	50μL/100μL
Target	AKR1B1
Reactivity	Human, Mouse, Rat
Applications	WB
MW(Calculated)
MW(Observed)	36kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	9D6
Immunogen	Purified recombinant human AKR1B1 protein fragments expressed in E.coli.
Specificity	This antibody detects endogenous levels of AKR1B1 and does not cross-react with related proteins.
Gene Name	AKR1B1
Protein Name
Other Name	ADR; / AKR1B 1; / Akr1b1; / Aldehyde reductase 1; / Aldehyde reductase; / Aldo keto reductase family 1, member B1; / Aldo-keto reductase family 1 member B1; / aldo-keto reductase family 1, member B1; / aldose reductase; / Aldose reductase; / aldr 1; / ALDR_HUMAN; / ALDR1; / ALR2; / AR; / Lii5 2 CTCL tumor antigen; / Low Km aldose reductase; / MGC1804.
Species	Human
Gene ID	231
Uniprot	P15121,
Species.1	Mouse
Gene ID.1	11677
Uniprot.1	P45376
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm.
Tissue Expression	Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
Signaling_pathway
Research Areas	>>Pentose and glucuronate interconversions; / >>Fructose and mannose metabolism; / >>Galactose metabolism; / >>Glycerolipid metabolism; / >>Folate biosynthesis; / >>Metabolic pathways
Function	Catalytic activity:Alditol + NAD(P)(+) = aldose + NAD(P)H.,Disease:In diabetes and galactosemia, increased AR activity leads to high levels of sorbitol and galactitol, respectively, in the cells of many tissues. Accumulation of sugar alcohols has been shown to cause osmotic cataracts in the lens. AR is also thought to play a key role in diabetic complications of three other target tissues, namely, nerve, kidney and retina.,enzyme regulation:Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis.,Function:Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,tissue specificity:Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.,

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AKR1B1 mouse mAb

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AKR1B1 mouse mAb

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