Specifications
| Size | 6mL |
| Target | Calponin-1 |
| Reactivity | Human |
| Applications | IHC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300 |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | 2°C to 8°C/1 year,Ship by ice bag |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM133 |
| Immunogen | Synthesized peptide derived from human Calponin-1 AA range: 100-200 |
| Specificity | The antibody can specifically recognize human and mouse calponin-1 protein. |
| Gene Name | CNN1 |
| Protein Name | Calponin-1 |
| Other Name | Calponin-1; / Basic calponin; / Calponin H1, smooth muscle |
| Species | Human |
| Gene ID | 1264 |
| Uniprot | P51911 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Smooth muscle, and tissues containing significant amounts of smooth muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.,similarity:Belongs to the calponin family.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 3 calponin-like repeats.,subunit:Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.,tissue specificity:Smooth muscle, and tissues containing significant amounts of smooth muscle., |
