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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Rabbit mAb/U-Blot® PI3-Kinase p110γ Rabbit mAb
SKU: WR4870 Categories: ,

U-Blot® PI3-Kinase p110γ Rabbit mAb

Ucallm_WR4870-50

Price range: $268.00 through $328.00

SKU: WR4870-50
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Product details

Background:Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015],

Specifications

Size50μL/100μL
TargetPI3-Kinase p110γ
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, IP, ELISA
MW(Calculated)127kD
MW(Observed)127kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM1040R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NamePIK3CG
Protein NamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Other NamePIK3CG; / Phosphatidylinositol 4; / 5-bisphosphate 3-kinase catalytic subunit gamma isoform; / PI3-kinase subunit gamma; / PI3K-gamma; / PI3Kgamma; / PtdIns-3-kinase subunit gamma; / Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit
SpeciesHuman
Gene ID5294
UniprotP48736,
Species.1Mouse
Gene ID.1
Uniprot.1Q9JHG7
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm . Cell membrane .
Tissue ExpressionPancreas, skeletal muscle, liver and heart.
Signaling_pathwayOrganismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Nervous system >> Cholinergic synapse;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas>>Inositol phosphate metabolism; / >>Metabolic pathways; / >>cGMP-PKG signaling pathway; / >>Chemokine signaling pathway; / >>Phospholipase D signaling pathway; / >>PI3K-Akt signaling pathway; / >>Adrenergic signaling in cardiomyocytes; / >>Apelin signaling pathway; / >>Platelet activation; / >>Cholinergic synapse; / >>Oxytocin signaling pathway; / >>Salmonella infection; / >>Toxoplasmosis; / >>Kaposi sarcoma-associated herpesvirus infection
FunctionCatalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,enzyme regulation:Activated by both the alpha and the beta-gamma G proteins.,Function:3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.,tissue specificity:Pancreas, skeletal muscle, liver and heart.,
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