Price range: $268.00 through $328.00
Background:domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle.,
| Size | 50μL/100μL |
| Target | TMEM16A |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 114kD |
| MW(Observed) | 130kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1068R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | ANO1 |
| Protein Name | Anoctamin-1 |
| Other Name | ANO1; / DOG1; / ORAOV2; / TAOS2; / TMEM16A; / Anoctamin-1; / Discovered on gastrointestinal stromal tumors protein 1; / Oral cancer overexpressed protein 2; / Transmembrane protein 16A; / Tumor-amplified and overexpressed sequence 2 |
| Species | Human |
| Gene ID | 55107 |
| Uniprot | Q5XXA6 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Cytoplasm . Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors. . |
| Tissue Expression | Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,Function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle., |
