Product details

Background:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010],

Specifications

Size	50μL/100μL
Target	2AAA
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	64kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human protein . at AA range: 500-580
Specificity	2AAA Polyclonal Antibody detects endogenous levels of protein.
Gene Name	PPP2R1A
Protein Name	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Other Name
Species	Human
Gene ID	5518
Uniprot	P30153,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q76MZ3
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Nucleus . Chromosome, centromere . Lateral cell membrane . Cell projection, dendrite . Centromeric localization requires the presence of BUB1. .
Tissue Expression	Brain,Cajal-Retzius cell,Colon,Placenta,Testis,
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle;Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Nervous system >> Dopaminergic synapse;Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Research Areas	>>mRNA surveillance pathway; / >>Sphingolipid signaling pathway; / >>Oocyte meiosis; / >>PI3K-Akt signaling pathway; / >>AMPK signaling pathway; / >>Adrenergic signaling in cardiomyocytes; / >>TGF-beta signaling pathway; / >>Hippo signaling pathway; / >>Tight junction; / >>Dopaminergic synapse; / >>Long-term depression; / >>Chagas disease; / >>Hepatitis C; / >>Human papillomavirus infection
Function	Domain:Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.,Function:The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.,similarity:Belongs to the phosphatase 2A regulatory subunit A family.,similarity:Contains 15 HEAT repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9.,

Please login to post questions

2AAA Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

2AAA Polyclonal Antibody

Product details

Specifications

Related products

U-Blot® SQSTM1/p62 Rabbit mAb

U-Blot® NQO1 Rabbit mAb

U-Blot® GAPDH Rabbit mAb

U-Blot® Glutamine Synthetase Rabbit mAb

U-Blot® Hsp90 Rabbit mAb

U-Blot® BID Rabbit mAb

Customer Reviews

Menu