Product details

Background:

function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., PTM:Palmitoylation is critical for proper membrane localization and signaling., PTM:Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation., similarity:Belongs to the G-alpha family. G(12) subfamily., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5.,

Specifications

Size	50μL/100μL
Target	GNA13
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	41kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	GNA13 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	GNA13
Protein Name	Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)
Other Name
Species	Human
Gene ID	10672
Uniprot	Q14344,
Species.1	Mouse
Gene ID.1
Uniprot.1	P27601
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Lipid-anchor . Melanosome . Cytoplasm . Nucleus . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424). .
Tissue Expression	Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level).
Signaling_pathway	Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas	>>cGMP-PKG signaling pathway; / >>Sphingolipid signaling pathway; / >>Phospholipase D signaling pathway; / >>Vascular smooth muscle contraction; / >>Apelin signaling pathway; / >>Platelet activation; / >>Long-term depression; / >>Regulation of actin cytoskeleton; / >>Parathyroid hormone synthesis, secretion and action; / >>Pathogenic Escherichia coli infection; / >>Human cytomegalovirus infection; / >>Pathways in cancer
Function	Function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.,PTM:Palmitoylation is critical for proper membrane localization and signaling.,PTM:Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.,similarity:Belongs to the G-alpha family. G(12) subfamily.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5.,

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GNA13 Polyclonal Antibody

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GNA13 Polyclonal Antibody

Product details

Specifications

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