Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | TRFM |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 81kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 210-290 |
| Specificity | TRFM Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MFI2 MAP97 |
| Protein Name | Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228) |
| Other Name | |
| Species | Human |
| Gene ID | 4241 |
| Uniprot | P08582, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9R0R1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Expression | Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.,similarity:Belongs to the transferrin family.,similarity:Contains 2 transferrin-like domains.,tissue specificity:Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts., |
