Product details
Background:
RP2 rabbit pAb
Ucallm_WP7026-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RP2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 39kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RP2 |
| Specificity | This antibody detects endogenous levels of RP2 at Human, Mouse |
| Gene Name | RP2 |
| Protein Name | Protein XRP2 |
| Other Name | |
| Species | Human |
| Gene ID | 6102 |
| Uniprot | O75695, |
| Species.1 | Mouse |
| Gene ID.1 | 19889 |
| Uniprot.1 | Q9EPK2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor; Cytoplasmic side . Cell projection, cilium . Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus. . |
| Tissue Expression | Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. |
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