Product details
Background:
AGAP2 rabbit pAb
Ucallm_WP8822-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | AGAP2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 131kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AGAP2 |
| Specificity | This antibody detects endogenous levels of AGAP2 at Human, Mouse,Rat |
| Gene Name | AGAP2 CENTG1 KIAA0167 |
| Protein Name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) |
| Other Name | |
| Species | Human |
| Gene ID | 116986 |
| Uniprot | Q99490, |
| Species.1 | Mouse |
| Gene ID.1 | 216439 |
| Uniprot.1 | Q3UHD9, |
| Species.2 | Rat |
| Gene ID.2 | 65218 |
| Uniprot.2 | Q8CGU4 |
| Cellular Localization | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm. |
| Tissue Expression | Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> FoxO signaling pathway |
| Research Areas | |
| Function | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. |
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