Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1, 3, 4, 5, 6-pentakisphosphate to form inositol-1, 2, 3, 4, 5, 6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010],
| Target | InsP5 2-kinase |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 56kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IPPK. AA range:11-60 |
| Sequence | |
| Specificity | InsP5 2-kinase Polyclonal Antibody detects endogenous levels of InsP5 2-kinase protein. |
| Gene Name | IPPK |
| Protein Name | Inositol-pentakisphosphate 2-kinase |
| Other Name | IPPK; / C9orf12; / Inositol-pentakisphosphate 2-kinase; / IPK1 homolog; / Inositol-1; / 3,4,5,6-pentakisphosphate 2-kinase; / Ins; / 1,3,4,5,6; / P5 2-kinase; / InsP5 2-kinase |
| Species | Human |
| Gene ID-1 | 64768 |
| Uniprot | Q9H8X2, |
| Species.1 | Mouse |
| Gene ID-2 | 75678 |
| Uniprot.1 | Q6P1C1, |
| Species.2 | Rat |
| Gene ID-3 | 306808 |
| Uniprot.2 | Q5PXE9 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010], |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Ubiquitously expressed, with high expression in heart, brain, testis and placenta. |
| Signaling_pathway | |
| Research Areas | >>Inositol phosphate metabolism; / >>Metabolic pathways; / >>Phosphatidylinositol signaling system |
| Function | Catalytic activity:ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.,Domain:The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.,Function:Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.,similarity:Belongs to the IPK1 type 2 family.,tissue specificity:Ubiquitously expressed, with high expression in heart, brain, testis and placenta., |
| RRID |
