Name: TRAP240 Polyclonal Antibody
SKU: WP14847
Price: 268 USD
Availability: InStock

TRAP240 Polyclonal Antibody

Ucallm_WP14847-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP14847-100

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Product details

Background:

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	TRAP240
Reactivity	Human, Mouse
Applications	IHC, IF, ELISA
MW(Calculated)	239kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human MED13. AA range:681-730
Specificity	TRAP240 Polyclonal Antibody detects endogenous levels of TRAP240 protein.
Gene Name	MED13
Protein Name	Mediator of RNA polymerase II transcription subunit 13
Other Name	MED13; / ARC250; / KIAA0593; / THRAP1; / TRAP240; / Mediator of RNA polymerase II transcription subunit 13; / Activator-recruited cofactor 250 kDa component; / ARC250; / Mediator complex subunit 13; / Thyroid hormone receptor-associated protein 1; / Thyroid ho
Species	Human
Gene ID	9969
Uniprot	Q9UHV7,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q5SWW4
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus.
Tissue Expression	Ubiquitous.
Signaling_pathway	Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway
Research Areas	>>Thyroid hormone signaling pathway
Function	Function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.,similarity:Belongs to the Mediator complex subunit 13 family.,subunit:Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.,tissue specificity:Ubiquitous.,