Price range: $268.00 through $328.00
Background:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH2 domain., similarity:Contains 1 SH3 domain., tissue specificity:Expressed in T-cells and some myeloid cell lines.,
| Size | 50μL/100μL |
| Target | Txk |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 61kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from the Internal region of human Txk. |
| Specificity | Txk Polyclonal Antibody detects endogenous levels of Txk protein. |
| Gene Name | TXK |
| Protein Name | Tyrosine-protein kinase TXK |
| Other Name | TXK; / PTK4; / RLK; / Tyrosine-protein kinase TXK; / Protein-tyrosine kinase 4; / Resting lymphocyte kinase |
| Species | Human |
| Gene ID | 7294 |
| Uniprot | P42681, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P42682 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Cell membrane; Peripheral membrane protein . Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells. |
| Tissue Expression | Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential. |
| Signaling_pathway | Organismal Systems >> Immune system >> Leukocyte transendothelial migration |
| Research Areas | >>Leukocyte transendothelial migration |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Expressed in T-cells and some myeloid cell lines., |
