SKU: WP16697 Categories: ,

ADAMTSL4 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16697-100
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Product details

Background:

This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014],

Specifications

Size50μL/100μL
TargetADAMTSL4
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)118kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ATL4 AA range: 78-128
SpecificityThis antibody detects endogenous levels of ATL4 at Human/Mouse/Rat
Gene NameADAMTSL4 TSRC1 PP1396 UNQ2803/PRO34012
Protein NameADAMTSL4
Other Name
SpeciesHuman
Gene ID54507
UniprotQ6UY14,
Species.1Mouse
Gene ID.1229595
Uniprot.1Q80T21,
Species.2Rat
Gene ID.2310670
Uniprot.2Q4FZU4
Cellular LocalizationSecreted, extracellular space, extracellular matrix . Colocalizes with FMN1 microfibrils in the eye ECM.
Tissue ExpressionExpressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lung and skeletal muscle, but weaker expression in fetal brain and skin.
Signaling_pathway
Research Areas
FunctionCaution:Although similar to members of the ADAMTS family, it lacks the metalloprotease and disintegrin-like domains which are typical of that family.,Function:Positive regulation of apoptosis.,similarity:Contains 1 PLAC domain.,similarity:Contains 6 TSP type-1 domains.,subunit:Interacts with CTSB.,
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