Name: 14-3-3-pan rabbit pAb
SKU: WP17688
Price: 268 USD
Availability: InStock

14-3-3-pan rabbit pAb

Ucallm_WP17688-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP17688-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	14-3-3-pan
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)	27kD
MW(Observed)	30kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human 14-3-3-pan
Specificity	This antibody detects endogenous levels of Human,Mouse,Rat 14-3-3-pan
Gene Name	YWHAB
Protein Name	14-3-3-pan
Other Name	14-3-3 protein beta/alpha; / Protein 1054; / Protein kinase C inhibitor protein 1; / KCIP-1; / [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Species	Human
Gene ID	7529
Uniprot	P31946;P61981;P27348;P63104;P31947,
Species.1	Mouse
Gene ID.1	54401
Uniprot.1	Q9CQV8,
Species.2	Rat
Gene ID.2	56011
Uniprot.2	P35213
Cellular Localization	Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Vacuole membrane . (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. .
Tissue Expression
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>Cell cycle; / >>Oocyte meiosis; / >>PI3K-Akt signaling pathway; / >>Hippo signaling pathway; / >>Hepatitis C; / >>Hepatitis B; / >>Viral carcinogenesis
Function	Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.,PTM:Isoform Short contains a N-acetylmethionine at position 1.,PTM:The alpha, brain-specific form differs from the beta form in being phosphorylated.,similarity:Belongs to the 14-3-3 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues.,