A2AP Polyclonal Antibody
Ucallm_WP0859-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
Specifications
| Size | 50μL/100μL |
| Target | A2AP |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 54kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 390-470 |
| Specificity | A2AP Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SERPINF2 AAP PLI |
| Protein Name | Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2) |
| Other Name | |
| Species | Human |
| Gene ID | 5345 |
| Uniprot | P08697, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61247 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Expressed by the liver and secreted in plasma. |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades |
| Research Areas | >>Complement and coagulation cascades |
| Function | Disease:Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]. APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis.,Function:The major targets of this inhibitor are plasmin and trypsin, but it also inactivates chymotrypsin.,similarity:Belongs to the serpin family.,tissue specificity:Expressed by the liver and secreted in plasma., |
Please login to post questions
Related products
