Name: AACT Polyclonal Antibody
SKU: WP15435
Price: 268 USD
Availability: InStock

AACT Polyclonal Antibody

Ucallm_WP15435-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP15435-100

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Product details

Background:

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	AACT
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	46kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human SERPINA3. AA range:251-300
Specificity	AACT Polyclonal Antibody detects endogenous levels of AACT protein.
Gene Name	SERPINA3
Protein Name	Alpha-1-antichymotrypsin
Other Name	SERPINA3; / AACT; / GIG24; / GIG25; / Alpha-1-antichymotrypsin; / ACT; / Cell growth-inhibiting gene 24/25 protein; / Serpin A3
Species	Human
Gene ID	12
Uniprot	P01011
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted.
Tissue Expression	Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Signaling_pathway
Research Areas
Function	Caution:It is uncertain whether Met-1 or Met-4 is the initiator.,Disease:Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].,Domain:The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.,Function:Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.,miscellaneous:Alpha-1-antichymotrypsin can bind DNA.,online information:Alpha-1 antichymotrypsin entry,sequence Caution:Translation N-terminally shortened.,similarity:Belongs to the serpin family.,subunit:Interacts with DNAJC1.,tissue specificity:Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the myloid plaques from the hippocampus of Alzheimer's disease brains.,

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AACT Polyclonal Antibody

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AACT Polyclonal Antibody

Product details

Specifications

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