ABLM1 Polyclonal Antibody
Ucallm_WP0819-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | ABLM1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 520-600 |
| Specificity | ABLM1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ABLIM1 ABLIM KIAA0059 LIMAB1 |
| Protein Name | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) |
| Other Name | |
| Species | Human |
| Gene ID | 3983 |
| Uniprot | O14639, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8K4G5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Associated with the cytoskeleton. . |
| Tissue Expression | Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Function:May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 HP (headpiece) domain.,similarity:Contains 2 LIM zinc-binding domains.,similarity:Contains 4 LIM zinc-binding domains.,subcellular location:Associated with the cytoskeleton.,subunit:Binds F-actin. Interacts with ABRA.,tissue specificity:Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers., |
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