Price range: $268.00 through $328.00
Background:
This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],
| Target | ACOT2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 53kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ACOT2. AA range:171-220 |
| Sequence | |
| Specificity | ACOT2 Polyclonal Antibody detects endogenous levels of ACOT2 protein. |
| Gene Name | ACOT2 |
| Protein Name | Acyl-coenzyme A thioesterase 2 mitochondrial |
| Other Name | ACOT2; / PTE2; / PTE2A; / Acyl-coenzyme A thioesterase 2; / mitochondrial; / Acyl-CoA thioesterase 2; / Acyl-coenzyme A thioester hydrolase 2a; / CTE-Ia; / Long-chain acyl-CoA thioesterase 2; / ZAP128 |
| Species | Human |
| Gene ID-1 | 10965 |
| Uniprot | P49753, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | Q9QYR9 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012], |
| Cellular Localization | Mitochondrion . |
| Tissue Expression | Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas. |
| Signaling_pathway | |
| Research Areas | >>Fatty acid elongation; / >>Biosynthesis of unsaturated fatty acids; / >>Metabolic pathways; / >>Ovarian steroidogenesis |
| Function | Catalytic activity:Palmitoyl-CoA + H(2)O = CoA + palmitate.,Caution:Was originally (PubMed:10944470) thought to be peroxisomal but was later shown (PubMed:16940157) to be mitochondrial.,Function:Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.,similarity:Belongs to the C/M/P thioester hydrolase family.,tissue specificity:Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas., |
| RRID |
