ADAMTS-19 Polyclonal Antibody
Ucallm_WP10951-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | ADAMTS-19 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 140kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADAMTS19. AA range:251-300 |
| Specificity | ADAMTS-19 Polyclonal Antibody detects endogenous levels of ADAMTS-19 protein. |
| Gene Name | ADAMTS19 |
| Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 19 |
| Other Name | ADAMTS19; / A disintegrin and metalloproteinase with thrombospondin motifs 19; / ADAM-TS 19; / ADAM-TS19; / ADAMTS-19 |
| Species | Human |
| Gene ID | 171019 |
| Uniprot | Q8TE59, |
| Species.1 | Mouse |
| Gene ID.1 | 240322 |
| Uniprot.1 | P59509 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted, extracellular space, extracellular matrix . |
| Tissue Expression | Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library. |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:Binds 1 zinc ion per subunit.,Domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library., |
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