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AGRIN Polyclonal Antibody
Ucallm_WP0847-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015],
Specifications
| Size | 50μL/100μL |
| Target | AGRIN |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 224kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1900-1980 |
| Specificity | AGRIN Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | AGRN AGRIN |
| Protein Name | Agrin |
| Other Name | |
| Species | Human |
| Gene ID | 375790 |
| Uniprot | O00468, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | A2ASQ1, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P25304 |
| Cellular Localization | [Isoform 1]: Secreted, extracellular space, extracellular matrix . Synaptic basal lamina at the neuromuscular junction. .; [Isoform 2]: Cell junction, synapse . Cell membrane; Single-pass type II membrane protein . |
| Tissue Expression | Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction |
| Research Areas | >>ECM-receptor interaction |
| Function | Function:Component of the basal lamina that causes the aggregation of acetylcholine receptors and acetylcholine-esterase on the surface of muscle fibers of the neuromuscular junction.,PTM:Contains heparan sulfate chains as well as N-linked and O-linked oligosaccharides.,similarity:Contains 1 NtA (N-terminal agrin) domain.,similarity:Contains 1 SEA domain.,similarity:Contains 2 laminin EGF-like domains.,similarity:Contains 3 laminin G-like domains.,similarity:Contains 4 EGF-like domains.,similarity:Contains 9 Kazal-like domains.,subcellular location:Synaptic basal lamina at the neuromuscular junction.,subunit:Binds to laminin., |
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