Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
| Size | 50μL/100μL |
| Target | AKR1CL2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 37kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AKR1CL2. AA range:141-190 |
| Specificity | AKR1CL2 Polyclonal Antibody detects endogenous levels of AKR1CL2 protein. |
| Gene Name | AKR1E2 |
| Protein Name | 1,5-anhydro-D-fructose reductase |
| Other Name | AKR1E2; / AKR1CL2; / AKRDC1; / 1; / 5-anhydro-D-fructose reductase; / AF reductase; / Aldo-keto reductase family 1 member C-like protein 2; / Aldo-keto reductase family 1 member E2; / LoopADR; / Testis-specific protein; / hTSP |
| Species | Human |
| Gene ID | 83592 |
| Uniprot | Q96JD6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9DCT1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Specifically expressed in testis (PubMed:12604216, PubMed:15118078). Expressed in testicular germ cells and testis interstitial cells (PubMed:15118078). |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH.,Function:Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones.,similarity:Belongs to the aldo/keto reductase family.,tissue specificity:Testis-specific., |
