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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Aldolase A Polyclonal Antibody
SKU: WP11012 Categories: ,

Aldolase A Polyclonal Antibody

Ucallm_WP11012-50

Price range: $268.00 through $328.00

SKU: WP11012-100
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Product details

Background:

The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1, 6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011],

Specifications

Size50μL/100μL
TargetALDOA
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)39kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human ALDOA. AA range:1-50
SpecificityAldolase A Polyclonal Antibody detects endogenous levels of Aldolase A protein.
Gene NameALDOA
Protein NameFructose-bisphosphate aldolase A
Other NameALDOA; / ALDA; / Fructose-bisphosphate aldolase A; / Lung cancer antigen NY-LU-1; / Muscle-type aldolase
SpeciesHuman
Gene ID226
UniprotP04075,
Species.1Mouse
Gene ID.111674
Uniprot.1P05064,
Species.2Rat
Gene ID.224189
Uniprot.2P05065
Cellular LocalizationCytoplasm, myofibril, sarcomere, I band . Cytoplasm, myofibril, sarcomere, M line . In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). .
Tissue ExpressionBrain,Cajal-Retzius cell,Cervix,Colon carcinoma,Epithelium,Eye,Feta
Signaling_pathwayEnvironmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Research Areas>>Glycolysis / Gluconeogenesis; / >>Pentose phosphate pathway; / >>Fructose and mannose metabolism; / >>Metabolic pathways; / >>Carbon metabolism; / >>Biosynthesis of amino acids; / >>HIF-1 signaling pathway
FunctionCatalytic activity:D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.,Disease:Defects in ALDOA are the cause of aldolase A deficiency [MIM:611881]; also known as aldoA deficiency or red cell aldolase deficiency. Aldolase A deficiency is an autosomal recessive disorder associated with hereditary hemolytic anemia.,miscellaneous:In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.,similarity:Belongs to the class I fructose-bisphosphate aldolase family.,subunit:Homotetramer.,
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