Amphiregulin Polyclonal Antibody
Ucallm_WP15638-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014],
Specifications
| Size | 50μL/100μL |
| Target | Amphiregulin |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 17kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human AREG/AREGB. AA range:91-140 |
| Specificity | Amphiregulin Polyclonal Antibody detects endogenous levels of Amphiregulin protein. |
| Gene Name | AREG/AREGB |
| Protein Name | Amphiregulin |
| Other Name | AREG; / SDGF; / AREGB; / Amphiregulin; / AR; / Colorectum cell-derived growth factor; / CRDGF |
| Species | Human |
| Gene ID | 374;727738 |
| Uniprot | P15514, |
| Species.1 | Mouse |
| Gene ID.1 | 11839 |
| Uniprot.1 | P31955, |
| Species.2 | Rat |
| Gene ID.2 | 29183 |
| Uniprot.2 | P24338 |
| Cellular Localization | Membrane; Single-pass membrane protein. |
| Tissue Expression | Brain,Pooled, |
| Signaling_pathway | Human Diseases >> Cancer: specific types >> Colorectal cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> ErbB signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>ErbB signaling pathway; / >>PI3K-Akt signaling pathway; / >>Hippo signaling pathway; / >>Colorectal cancer |
| Function | Function:Bifunctional growth-modulating glycoprotein. Inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells.,induction:By phorbol 12-myristate 13-acetate (PMA).,miscellaneous:AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.,similarity:Belongs to the amphiregulin family.,similarity:Contains 1 EGF-like domain.,subunit:The immature precursor interacts with CNIH., |
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