Price range: $268.00 through $328.00
Background:
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
| Size | 50μL/100μL |
| Target | AMRP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 39kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AMRP AA range: 277-327 |
| Specificity | This antibody detects endogenous levels of AMRP at Human/Mouse/Rat |
| Gene Name | LRPAP1 A2MRAP |
| Protein Name | AMRP |
| Other Name | |
| Species | Human |
| Gene ID | 4043 |
| Uniprot | P30533, |
| Species.1 | Mouse |
| Gene ID.1 | 16976 |
| Uniprot.1 | P55302, |
| Species.2 | Rat |
| Gene ID.2 | 116565 |
| Uniprot.2 | Q99068 |
| Cellular Localization | Rough endoplasmic reticulum lumen . Endoplasmic reticulum-Golgi intermediate compartment lumen . Golgi apparatus, cis-Golgi network . Golgi apparatus lumen . Endosome lumen . Cell surface . May be associated with receptors at the cell surface. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Cholesterol metabolism |
| Function | Disease:In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.,Function:Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.,PTM:N-glycosylated.,similarity:Belongs to the alpha-2-MRAP family.,subcellular location:Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum.,subunit:Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation., |
