ANKT Polyclonal Antibody
Ucallm_WP11049-50
Price range: $268.00 through $328.00
Product details
Background:
NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009],
Specifications
| Size | 50μL/100μL |
| Target | ANKT |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 49kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NUSAP1. AA range:392-441 |
| Specificity | ANKT Polyclonal Antibody detects endogenous levels of ANKT protein. |
| Gene Name | NUSAP1 |
| Protein Name | Nucleolar and spindle-associated protein 1 |
| Other Name | NUSAP1; / ANKT; / BM-037; / Nucleolar and spindle-associated protein 1; / NuSAP |
| Species | Human |
| Gene ID | 51203 |
| Uniprot | Q9BXS6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9ERH4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus, nucleolus . Cytoplasm, cytoskeleton, spindle . Chromosome . Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis. . |
| Tissue Expression | Bone marrow,Cervix,Epithelium,Fetal liver,Liver,Lung,Lymph, |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.,Function:Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein.,similarity:Belongs to the NUSAP family.,subcellular location:Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis.,subunit:Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2., |
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