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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/APPL1 Polyclonal Antibody
SKU: WP11088 Categories: ,

APPL1 Polyclonal Antibody

Ucallm_WP11088-50

Price range: $268.00 through $328.00

SKU: WP11088-100
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Product details

Background:

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1(APPL1) Homo sapiens The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetAPPL1
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)80kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human APPL1. AA range:121-170
SpecificityAPPL1 Polyclonal Antibody detects endogenous levels of APPL1 protein.
Gene NameAPPL1
Protein NameDCC-interacting protein 13-alpha
Other NameAPPL1; / APPL; / DIP13A; / KIAA1428; / DCC-interacting protein 13-alpha; / Dip13-alpha; / Adapter protein containing PH domain; / PTB domain and leucine zipper motif 1
SpeciesHuman
Gene ID26060
UniprotQ9UKG1,
Species.1Mouse
Gene ID.172993
Uniprot.1Q8K3H0
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEarly endosome membrane; Peripheral membrane protein . Nucleus . Cytoplasm . Endosome . Cell projection, ruffle . Cytoplasmic vesicle, phagosome . Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. .
Tissue ExpressionHigh levels in heart, ovary, pancreas and skeletal muscle.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Colorectal cancer
Research Areas>>Longevity regulating pathway; / >>Pathways in cancer; / >>Colorectal cancer
FunctionDomain:Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.,Function:Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 PH domain.,similarity:Contains 1 PID domain.,subcellular location:Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.,subunit:Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex.,tissue specificity:High levels in heart, ovary, pancreas and skeletal muscle.,
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