AQP0 Polyclonal Antibody
Ucallm_WP11091-50
Price range: $268.00 through $328.00
Product details
Background:
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | AQP0 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 28kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AQP0. AA range:95-144 |
| Specificity | AQP0 Polyclonal Antibody detects endogenous levels of AQP0 protein. |
| Gene Name | MIP |
| Protein Name | Lens fiber major intrinsic protein |
| Other Name | MIP; / AQP0; / Lens fiber major intrinsic protein; / Aquaporin-0; / MIP26; / MP26 |
| Species | Human |
| Gene ID | 4284 |
| Uniprot | P30301, |
| Species.1 | Mouse |
| Gene ID.1 | 17339 |
| Uniprot.1 | P51180, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P09011 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Cell junction, gap junction . |
| Tissue Expression | Expressed in the cortex and nucleus of the retina lens (at protein level) (PubMed:30790544). Major component of lens fiber gap junctions (PubMed:24120416). |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in MIP are a cause of autosomal recessive congenital cataract [MIM:154050].,Domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,Function:Water channel. May be responsible for regulating the osmolarity of the lens.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,tissue specificity:Major component of lens fiber gap junctions., |
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