Product details
Background:
ARF1 rabbit pAb
Ucallm_WP6092-50
Price range: $268.00 through $328.00
Specifications
| Target | ARF1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 20kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ARF1 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of ARF1 at Human, Mouse,Rat |
| Gene Name | ARF1 |
| Protein Name | ADP-ribosylation factor 1 |
| Other Name | |
| Species | Human |
| Gene ID-1 | 375 |
| Uniprot | P84077, |
| Species.1 | Mouse |
| Gene ID-2 | 11840 |
| Uniprot.1 | P84078, |
| Species.2 | Rat |
| Gene ID-3 | 64310 |
| Uniprot.2 | P84079 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Golgi apparatus . Cytoplasm, perinuclear region . Cell junction, synapse, synaptosome . Cell junction, synapse, postsynaptic density . Membrane; Lipid-anchor . Golgi apparatus, trans-Golgi network membrane; Lipid-anchor . |
| Tissue Expression | |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway |
| Research Areas | |
| Function | GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).; (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. |
| RRID |
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