Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human ARHGAP21
Specificity
This antibody detects endogenous levels of ARHGAP21 at Human, Mouse
Gene Name
ARHGAP21 ARHGAP10 KIAA1424
Protein Name
Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)
Other Name
Species
Human
Gene ID
57584
Uniprot
Q5T5U3,
Species.1
Mouse
Gene ID.1
71435
Uniprot.1
Q6DFV3
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
Tissue Expression
Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.
Signaling_pathway
Research Areas
Function
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.