Price range: $268.00 through $328.00
Background:
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | ARHGAP23 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, WB, ELISA |
| MW(Calculated) | 162kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from ARHGAP23 . at AA range: 470-550 |
| Specificity | ARHGAP23 Polyclonal Antibody detects endogenous levels of ARHGAP23 protein. |
| Gene Name | ARHGAP23 |
| Protein Name | Rho GTPase-activating protein 23 |
| Other Name | ARHGAP23; / KIAA1501; / Rho GTPase-activating protein 23; / Rho-type GTPase-activating protein 23 |
| Species | Human |
| Gene ID | 57636 |
| Uniprot | Q9P227, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q69ZH9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytosol,extracellular exosome, |
| Tissue Expression | Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor., |
