Price range: $268.00 through $328.00
Background:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010],
| Size | 50μL/100μL |
| Target | ARHGF |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 92kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 560-640 |
| Specificity | ARHGF Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ARHGEF15 KIAA0915 |
| Protein Name | Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) |
| Other Name | |
| Species | Human |
| Gene ID | 22899 |
| Uniprot | O94989, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q5FWH6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell projection, dendrite . Expressed exclusively in dendrites of the developing hippocampus. . |
| Tissue Expression | Expressed in the vascular smooth muscle of coronary artery. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Specific GEF for RhoA activation and the regulation of vascular smooth muscle contractility.,PTM:Phosphorylated on tyrosine residues upon EFNA1 stimulation.,similarity:Contains 1 DH (DBL-homology) domain.,subunit:Interacts with EPHA4.,tissue specificity:Expressed in the vascular smooth muscle of coronary artery., |
