Price range: $268.00 through $328.00
Background:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],
| Size | 50μL/100μL |
| Target | ARPC5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 17kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ARPC5 AA range: 58-108 |
| Specificity | This antibody detects endogenous levels of ARPC5 at Human/Mouse/Rat |
| Gene Name | ARPC5 ARC16 |
| Protein Name | ARPC5 |
| Other Name | |
| Species | Human |
| Gene ID | 10092 |
| Uniprot | O15511, |
| Species.1 | Mouse |
| Gene ID.1 | 67771 |
| Uniprot.1 | Q9CPW4, |
| Species.2 | Rat |
| Gene ID.2 | 360854 |
| Uniprot.2 | Q4KLF8 |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection . Nucleus . |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis |
| Research Areas | >>Endocytosis; / >>Tight junction; / >>Fc gamma R-mediated phagocytosis; / >>Regulation of actin cytoskeleton; / >>Bacterial invasion of epithelial cells; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Yersinia infection |
| Function | Function:Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.,similarity:Belongs to the ARPC5 family.,subunit:Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC., |
