Arrestin-β-2 Monoclonal Antibody
Ucallm_WM0475-50
Price range: $268.00 through $328.00
Product details
Background:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012],
Specifications
| Size | 50μL/100μL |
| Target | Arrestin-β-2 |
| Reactivity | Human, Mouse, Rat, Pig |
| Applications | WB, IF |
| MW(Calculated) | 46kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-1:2000; IF 1:100-1:500; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 15A11 |
| Immunogen | Purified recombinant human Arrestin-β-2 (C-terminus) protein fragments expressed in E.coli. |
| Specificity | Arrestin-β-2 Monoclonal Antibody detects endogenous levels of Arrestin-β-2 protein. |
| Gene Name | ARRB2 |
| Protein Name | Beta-arrestin-2 |
| Other Name | ARRB2; / ARB2; / ARR2; / Beta-arrestin-2; / Arrestin beta-2 |
| Species | Human |
| Gene ID | 409 |
| Uniprot | P32121, |
| Species.1 | Mouse |
| Gene ID.1 | 216869 |
| Uniprot.1 | Q91YI4, |
| Species.2 | Rat |
| Gene ID.2 | 25388 |
| Uniprot.2 | P29067 |
| Cellular Localization | Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. |
| Tissue Expression | Brain,Cord blood,Endometrium,Muscle,Pancreas,Testis,Thyroid, |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Nervous system >> Dopaminergic synapse;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Chemokine signaling pathway; / >>Endocytosis; / >>Hedgehog signaling pathway; / >>Dopaminergic synapse; / >>Olfactory transduction; / >>Relaxin signaling pathway; / >>Parathyroid hormone synthesis, secretion and action; / >>GnRH secretion; / >>Morphine addiction; / >>Chemical carcinogenesis - receptor activation |
| Function | Function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family., |
Please login to post questions
Related products
