Price range: $268.00 through $328.00
Background:
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010],
| Size | 50μL/100μL |
| Target | ASAH3L |
| Reactivity | Human, Mouse, Monkey |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 33kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from ASAH3L . at AA range: 50-130 |
| Specificity | ASAH3L Polyclonal Antibody detects endogenous levels of ASAH3L protein. |
| Gene Name | ACER2 |
| Protein Name | Alkaline ceramidase 2 |
| Other Name | ACER2; / ASAH3L; / PP11646; / Alkaline ceramidase 2; / AlkCDase 2; / Alkaline CDase 2; / haCER2; / Acylsphingosine deacylase 3-like; / N-acylsphingosine amidohydrolase 3-like |
| Species | Human |
| Gene ID | 340485 |
| Uniprot | Q5QJU3, |
| Species.1 | Mouse |
| Gene ID.1 | 230379 |
| Uniprot.1 | Q8VD53 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus membrane; Multi-pass membrane protein . |
| Tissue Expression | Highly expressed in placenta. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway |
| Research Areas | >>Sphingolipid metabolism; / >>Metabolic pathways; / >>Sphingolipid signaling pathway |
| Function | Catalytic activity:N-acylsphingosine + H(2)O = a carboxylate + sphingosine.,Function:Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.,similarity:Belongs to the alkaline ceramidase family., |
