Name: ASIC3 Polyclonal Antibody
SKU: WP15276
Price: 268 USD
Availability: InStock

Product details

Background:

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012],

Specifications

Size	50μL/100μL
Target	ASIC3
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	58kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human ASIC3. AA range:191-240
Specificity	ASIC3 Polyclonal Antibody detects endogenous levels of ASIC3 protein.
Gene Name	ASIC3
Protein Name	Acid-sensing ion channel 3
Other Name	ASIC3; / ACCN3; / SLNAC1; / TNAC1; / Acid-sensing ion channel 3; / ASIC3; / hASIC3; / Amiloride-sensitive cation channel 3; / Neuronal amiloride-sensitive cation channel 3; / Testis sodium channel 1; / hTNaC1
Species	Human
Gene ID	9311
Uniprot	Q9UHC3,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q6X1Y6
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Multi-pass membrane protein . Cytoplasm . Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). .
Tissue Expression	Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
Signaling_pathway	Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Research Areas	>>Inflammatory mediator regulation of TRP channels
Function	developmental stage:Expressed in fetal tissues, expression increases in lung and kidney adult tissues.,Domain:The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1.,Function:Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.,miscellaneous:Potentiated by FMRFamide-related neuropeptides. Sensitized and potentiated by NPSF. Regulated by lactate and Ca(2+). Inhibited by anti-inflammatory drugs, like salicylic acid (By similarity). Sensitized and potentiated by NPFF.,PTM:Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ACCN3/ASIC3-ACCN1/ASIC2b channel, but does not activate a homomeric ACCN3 channel.,similarity:Belongs to the amiloride-sensitive sodium channel family.,subcellular location:Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells.,subunit:Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM and DLG4 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ACCN1.,tissue specificity:Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.,

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ASIC3 Polyclonal Antibody

Product details

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ASIC3 Polyclonal Antibody

Product details

Specifications

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