Name: ATP-Citrate Lyase [C-term] mouse mAb
SKU: WM0593
Price: 268 USD
Availability: InStock

ATP-Citrate Lyase [C-term] mouse mAb

Ucallm_WM0593-50

Price range: $268.00 through $328.00

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SKU: WM0593-50

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Product details

Background:
ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],

Specifications

Target	ATP-citrate synthase
Reactivity	Human, Mouse, Monkey
Applications	WB, ICC, FC
MW(Calculated)
MW(Observed)	120kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:1000; ICC 1:150; Flow Cyt 1:100
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	70000
Immunogen	Purified recombinant human ATP-Citrate Lyase protein fragments expressed in E.coli.
Sequence
Specificity	This antibody detects endogenous levels of ATP-Citrate Lyase and does not cross-react with related proteins.
Gene Name	acly
Protein Name
Other Name	ACL; / Acly; / ACLY_HUMAN; / ATP citrate; / pro-S; / lyase; / ATP citrate lyase; / ATP citrate synthase; / ATP-citrate; / pro-S-; / -lyase; / ATP-citrate synthase; / ATPcitrate synthase; / ATPCL; / Citrate cleavage enzyme; / CLATP; / OTTHUMP00000164773.
Species	Human
Gene ID-1	47
Uniprot	P53396,
Species.1	Mouse
Gene ID-2	104112
Uniprot.1	Q91V92
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],
Cellular Localization	Cytoplasm, cytosol .
Tissue Expression	Brain,Epithelium,Hippocampus,Liver,Lymph,Platelet,
Signaling_pathway
Research Areas	>>Citrate cycle (TCA cycle); / >>Metabolic pathways
Function	Catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.,Function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.,subunit:Homotetramer.,
RRID

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ATP-Citrate Lyase [C-term] mouse mAb

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ATP-Citrate Lyase [C-term] mouse mAb

Product details

Specifications

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