B4GT4 Polyclonal Antibody
Ucallm_WP0927-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is one of seven beta-1, 4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1, 4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcrip
Specifications
| Size | 50μL/100μL |
| Target | B4GT4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 37kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | B4GT4 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | B4GALT4 UNQ552/PRO1109 |
| Protein Name | Beta-1,4-galactosyltransferase 4 (Beta-1,4-GalTase 4) (Beta4Gal-T4) (b4Gal-T4) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4) [Includes: N-acetyllactosamine synthase (Nal synthase); Lactotriaosylceramide beta-1,4-galactosyltransferase (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase)] |
| Other Name | |
| Species | Human |
| Gene ID | 8702 |
| Uniprot | O60513, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JJ04, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q66HH1 |
| Cellular Localization | Golgi apparatus membrane; Single-pass type II membrane protein . Secreted . |
| Tissue Expression | Highest expression is observed in placenta, pancreas, kidney and heart (PubMed:9792633). Expressed in corneal epithelial cells (PubMed:17690104). |
| Signaling_pathway | |
| Research Areas | >>Glycosaminoglycan biosynthesis - keratan sulfate; / >>Glycosphingolipid biosynthesis - lacto and neolacto series; / >>Metabolic pathways |
| Function | Catalytic activity:UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.,cofactor:Manganese.,Function:Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.,online information:Beta-1,4-galactosyltransferase 4,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 7 family.,subcellular location:Trans cisternae of Golgi stack.,tissue specificity:High expression in heart, placenta, kidney and pancreas; lower in brain, colon, lung, muscle, ovary, testis and uterus., |
Please login to post questions
Related products
