Price range: $268.00 through $328.00
Background:
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008],
| Size | 50μL/100μL |
| Target | BMP-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic peptide from human protein at AA range: 131-180 |
| Specificity | The antibody detects endogenous BMP-1 |
| Gene Name | BMP1 PCOLC |
| Protein Name | Bone morphogenetic protein 1 (BMP-1) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) |
| Other Name | Bone morphogenetic protein 1; / BMP-1; / Mammalian tolloid protein; / mTld; / Procollagen C-proteinase; / PCP |
| Species | Human |
| Gene ID | 649 |
| Uniprot | P13497, |
| Species.1 | Mouse |
| Gene ID.1 | 12153 |
| Uniprot.1 | P98063 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus, trans-Golgi network . Secreted, extracellular space, extracellular matrix . Secreted . Co-localizes with POSTN in the Golgi. .; [Isoform BMP1-3]: Secreted . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Activity is increased by the procollagen C-endopeptidase enhancer protein.,Function:Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD).,similarity:Belongs to the peptidase M12A family.,similarity:Contains 2 EGF-like domains.,similarity:Contains 5 CUB domains.,tissue specificity:Ubiquitous., |
