Brn-3a Polyclonal Antibody
Ucallm_WP11310-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012],
Specifications
| Size | 50μL/100μL |
| Target | Brn-3a |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human POU4F1. AA range:311-360 |
| Specificity | Brn-3a Polyclonal Antibody detects endogenous levels of Brn-3a protein. |
| Gene Name | POU4F1 |
| Protein Name | POU domain class 4 transcription factor 1 |
| Other Name | POU4F1; / BRN3A; / RDC1; / POU domain; / class 4, transcription factor 1; / Brain-specific homeobox/POU domain protein 3A; / Brain-3A; / Brn-3A; / Homeobox/POU domain protein RDC-1; / Oct-T1 |
| Species | Human |
| Gene ID | 5457 |
| Uniprot | Q01851, |
| Species.1 | Mouse |
| Gene ID.1 | 18996 |
| Uniprot.1 | P17208, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P20266 |
| Cellular Localization | Nucleus . Cytoplasm . |
| Tissue Expression | Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye. |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Expression peaks early in embryogenesis (day 13.5) and is undetectable 14 days after birth.,Function:Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.,similarity:Belongs to the POU transcription factor family. Class-4 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,tissue specificity:Brain. Seems to be specific to the retina. Present in the developing brain, spinal cord and eye., |
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