Price range: $268.00 through $328.00
Background:
This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011],
| Size | 50μL/100μL |
| Target | BTBD9 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 67kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human BTBD9 AA range: 424-474 |
| Specificity | This antibody detects endogenous levels of BTBD9 at Human/Mouse/Rat |
| Gene Name | BTBD9 KIAA1880 |
| Protein Name | BTBD9 |
| Other Name | |
| Species | Human |
| Gene ID | 114781 |
| Uniprot | Q96Q07, |
| Species.1 | Mouse |
| Gene ID.1 | 224671 |
| Uniprot.1 | Q8C726, |
| Species.2 | Rat |
| Gene ID.2 | 294318 |
| Uniprot.2 | Q5PQR3 |
| Cellular Localization | cytoplasm,SCF ubiquitin ligase complex, |
| Tissue Expression | Detected in the brain (at protein level) (PubMed:22658601). Moderately expressed in all specific brain regions examined (PubMed:11572484). Expressed in the dopaminergic neurons of the substantia nigra and A11 neurons (PubMed:22658601). Highly expressed in kidney and moderately expressed in all other adult and fetal tissues (PubMed:11572484). |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Genetic variations in BTBD9 are associated with susceptibility to restless legs syndrome type 6 (RLS6) [MIM:611185]; also called periodic limb movements in sleep. Restless legs syndrome (RLS) is a neurologic disorder characterized by an uncontrollable urge to move the legs during periods of rest. The majority of patients with RLS also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.,similarity:Contains 1 BACK (BTB/Kelch associated) domain.,similarity:Contains 1 BTB (POZ) domain.,tissue specificity:Highly expressed in kidney and moderately expressed in all other adult and fetal tissues. Moderately expressed in all specific brain regions examined., |
