Name: C/EBP β Monoclonal Antibody
SKU: WM0066
Price: 268 USD
Availability: InStock

Product details

Background:
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013],

Specifications

Target	C/EBP β
Reactivity	Human
Applications	WB, FC, ELISA
MW(Calculated)	36kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	Affinity purification
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	9C1
Immunogen	Purified recombinant fragment of human C/EBP β expressed in E. Coli.
Sequence
Specificity	C/EBP β Monoclonal Antibody detects endogenous levels of C/EBP β protein.
Gene Name	CEBPB
Protein Name	CCAAT/enhancer-binding protein beta
Other Name	CEBPB; / LAP; / TCF5; / PP9092; / CCAAT/enhancer-binding protein beta; / C/EBP beta; / Liver activator protein; / Nuclear factor NF-IL6; / Transcription factor 5; / TCF-5
Species	Human
Gene ID-1	1051
Uniprot	P17676,
Species.1	Mouse
Gene ID-2	12608
Uniprot.1	P28033
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013],
Cellular Localization	Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). .
Tissue Expression	Expressed at low levels in the lung, kidney and spleen.
Signaling_pathway	Organismal Systems >> Immune system >> IL-17 signaling pathway;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Research Areas	>>IL-17 signaling pathway; / >>TNF signaling pathway; / >>Tuberculosis; / >>Transcriptional misregulation in cancer
Function	Function:Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'.,PTM:Sumoylated by polymeric chains of SUMO2 or SUMO3.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2.,tissue specificity:Expressed at low levels in the lung, kidney and spleen.,
RRID

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C/EBP β Monoclonal Antibody

Product details

Specifications

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C/EBP β Monoclonal Antibody

Product details

Specifications

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