Product details
Background:
- Please choose product options by visiting C22orf41 rabbit pAb.
- Please choose product options by visiting C10orf67 rabbit pAb.
C6orf134 rabbit pAb
Ucallm_WP8782-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ATAT1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 46kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human C6orf134 |
| Specificity | This antibody detects endogenous levels of C6orf134 at Human, Mouse,Rat |
| Gene Name | ATAT1 C6orf134 MEC17 Nbla00487 |
| Protein Name | Alpha-tubulin N-acetyltransferase (Alpha-TAT) (TAT) (Acetyltransferase mec-17 homolog) |
| Other Name | |
| Species | Human |
| Gene ID | 79969 |
| Uniprot | Q5SQI0, |
| Species.1 | Mouse |
| Gene ID.1 | 73242 |
| Uniprot.1 | Q8K341, |
| Species.2 | Rat |
| Gene ID.2 | 361789 |
| Uniprot.2 | Q6MG11 |
| Cellular Localization | Cytoplasm . Membrane, clathrin-coated pit . Cell junction, focal adhesion . Cell projection, axon . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. |
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