CARKL Polyclonal Antibody
Ucallm_WP11410-50
Price range: $268.00 through $328.00
Product details
Background:
sedoheptulokinase(SHPK) Homo sapiens The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CARKL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CARKL. AA range:31-80 |
| Specificity | CARKL Polyclonal Antibody detects endogenous levels of CARKL protein. |
| Gene Name | SHPK |
| Protein Name | Sedoheptulokinase |
| Other Name | SHPK; / CARKL; / Sedoheptulokinase; / SHK; / Carbohydrate kinase-like protein |
| Species | Human |
| Gene ID | 23729 |
| Uniprot | Q9UHJ6, |
| Species.1 | Mouse |
| Gene ID.1 | 74637 |
| Uniprot.1 | Q9D5J6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain. |
| Signaling_pathway | |
| Research Areas | >>Metabolic pathways |
| Function | Catalytic activity:ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate.,Disease:Deficiency of the SHPK gene in cystinosis patients with a common 57-Kb deletion causes urinary accumulation of sedoheptulose and erythritol.,similarity:Belongs to the FGGY kinase family.,tissue specificity:Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain., |
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