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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Casein Kinase Iα Polyclonal Antibody
SKU: WP11416 Categories: ,

Casein Kinase Iα Polyclonal Antibody

Ucallm_WP11416-50

Price range: $268.00 through $328.00

SKU: WP11416-100
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Product details

Background:

catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on ‘Ser-45’., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily., similarity:Contains 1 protein kinase domain., subunit:Monomer. Interacts with the Axin complex.,

Specifications

TargetCasein Kinase Iα
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)35kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CKI-alpha. AA range:126-175
Sequence
SpecificityCasein Kinase Iα Polyclonal Antibody detects endogenous levels of Casein Kinase Iα protein.
Gene NameCSNK1A1
Protein NameCasein kinase I isoform alpha
Other NameCSNK1A1; / Casein kinase I isoform alpha; / CKI-alpha; / CK1
SpeciesHuman
Gene ID-11452
UniprotP48729,
Species.1Mouse
Gene ID-2
Uniprot.1Q8BK63,
Species.2Rat
Gene ID-3113927
Uniprot.2P97633
Organism-4
Gene ID-4
SwissProt-4
Backgroundcatalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,
Cellular LocalizationCytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, spindle . Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). .
Tissue ExpressionBrain,Epithelium,Liver,Lung,Placenta,Skin,
Signaling_pathwayHuman Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway
Research Areas>>Wnt signaling pathway; / >>Hedgehog signaling pathway; / >>Alzheimer disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Human papillomavirus infection; / >>Breast cancer; / >>Hepatocellular carcinoma; / >>Gastric cancer
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,
RRID
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