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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/Casein Kinase Iα Monoclonal Antibody
SKU: WM0073 Categories: ,

Casein Kinase Iα Monoclonal Antibody

Ucallm_WM0073-50

Price range: $268.00 through $328.00

SKU: WM0073-50
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Product details

Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on ‘Ser-45’., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily., similarity:Contains 1 protein kinase domain., subunit:Monomer. Interacts with the Axin complex.,

Specifications

Size50μL/100μL
TargetCasein Kinase Iα
ReactivityHuman
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)39kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number17B11
ImmunogenPurified recombinant fragment of Casein Kinase Iα expressed in E. Coli.
SpecificityCasein Kinase Iα Monoclonal Antibody detects endogenous levels of Casein Kinase Iα protein.
Gene NameCSNK1A1
Protein NameCasein kinase I isoform alpha
Other NameCSNK1A1; / Casein kinase I isoform alpha; / CKI-alpha; / CK1
SpeciesHuman
Gene ID1452
UniprotP48729,
Species.1Mouse
Gene ID.1
Uniprot.1Q8BK63
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, spindle . Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). .
Tissue ExpressionBrain,Epithelium,Liver,Lung,Placenta,Skin,
Signaling_pathwayHuman Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway
Research Areas>>Wnt signaling pathway; / >>Hedgehog signaling pathway; / >>Alzheimer disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Human papillomavirus infection; / >>Breast cancer; / >>Hepatocellular carcinoma; / >>Gastric cancer
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,
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