Price range: $268.00 through $328.00
Background:
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | CCK-AR |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 44kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CCKAR. AA range:215-264 |
| Specificity | CCK-AR Polyclonal Antibody detects endogenous levels of CCK-AR protein. |
| Gene Name | CCKAR |
| Protein Name | Cholecystokinin receptor type A |
| Other Name | CCKAR; / CCKRA; / Cholecystokinin receptor type A; / CCK-A receptor; / CCK-AR; / Cholecystokinin-1 receptor; / CCK1-R |
| Species | Human |
| Gene ID | 886 |
| Uniprot | P32238, |
| Species.1 | Mouse |
| Gene ID.1 | 12425 |
| Uniprot.1 | O08786, |
| Species.2 | Rat |
| Gene ID.2 | 24889 |
| Uniprot.2 | P30551 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Gall bladder,Peripheral blood leukocyte,Stomach, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Insulin secretion;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Calcium signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Insulin secretion; / >>Pancreatic secretion |
| Function | Function:Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Cholecystokinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family., |
