Name: U-Blot® CD11c Rabbit mAb
SKU: WR4672
Price: 268 USD
Availability: InStock

U-Blot® CD11c Rabbit mAb

Western Blot analysis using THP-1 lysates,primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(WS0446)was diluted at 1:10000, 37° 1hour.

WR4672 Western Blot analysis using THP-1 lysates,primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(WS0446)was diluted at 1:10000, 37° 1hour.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4672-50

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Product details

Background:integrin subunit alpha X(ITGAX) Homo sapiens This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013],

Specifications

Size	50μL/100μL
Target	CD11c
Reactivity	Human
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	128kD
MW(Observed)	145kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0885R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	ITGAX CD11C
Protein Name	Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)
Other Name	Integrin alpha-X; / CD11 antigen-like family member C; / Leu M5; / Leukocyte adhesion glycoprotein p150,95 alpha chain; / Leukocyte adhesion receptor p150,95; / CD antigen CD11c
Species	Human
Gene ID	3687
Uniprot	P20702,
Species.1	Mouse
Gene ID.1	16411
Uniprot.1	Q9QXH4
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Membrane; Single-pass type I membrane protein.
Tissue Expression	Predominantly expressed in monocytes and granulocytes.
Signaling_pathway	Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Complement and coagulation cascades
Research Areas	>>Complement and coagulation cascades; / >>Regulation of actin cytoskeleton; / >>Tuberculosis
Function	Domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,Function:Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.,tissue specificity:Predominantly expressed in monocytes and granulocytes.,