U-Blot® CD206/MRC1 Rabbit mAb
WR4322 Mouse liver cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with primary antibody 1:1000. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.
Price range: $268.00 through $328.00
Product details
Background:The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],
Specifications
| Size | 50μL/100μL |
| Target | CD206 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 166kD |
| MW(Observed) | 190kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:5000-1:20000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0527R |
| Immunogen | Synthesized peptide derived from human N-ternal CD206 |
| Specificity | Endogenous |
| Gene Name | MRC1 |
| Protein Name | Macrophage mannose receptor 1 |
| Other Name | MRC1; / CLEC13D; / CLEC13DL; / MRC1L1; / Macrophage mannose receptor 1; / MMR; / C-type lectin domain family 13 member D; / C-type lectin domain family 13 member D-like; / Macrophage mannose receptor 1-like protein 1; / CD206 |
| Species | Human |
| Gene ID | 4360 |
| Uniprot | P22897, |
| Species.1 | Mouse |
| Gene ID.1 | 17533 |
| Uniprot.1 | Q61830 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane |
| Tissue Expression | Milk,Placenta,Testis, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome |
| Research Areas | >>Phagosome; / >>Tuberculosis |
| Function | Function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains., |
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